Identification and Quantitation of Nicotine Polacrilex in Nicotine Pouches and Other Oral Nicotine Delivery Products

SUMMARY Nicotine polacrilex (CAS-No. 96055-45-7) can be used as the source of nicotine in pouches and other oral delivery products such lozenges, tablets, gums. The compound is salt with Amberlite IRP64, a copolymer methacrylic acid divinylbenzene. Present study describes unique procedure to identify presence evaluate its level. In products, mixture ingredients microcrystalline cellulose (MCC), maltitol, sweeteners, flavors, salts (such Na 2 CO 3 , NaHCO ), water, etc. These make analysis by spectroscopic techniques IR or Raman difficult. Also, since insoluble common solvents, using solutions not possible. also attempting detect if product contains only it has additional different form (e.g., tartrate). uses pyrolysis-GC/MS (Py-GC/MS) detection quantitation based on measuring pyrolysis divinylbenzene (DVB) moiety from IRP64. was proven very reliable this procedure, while showed some variability caused typical process. [Contrib. Tob. Res. 32 (2023) 43–49]